Bezafibrate has an antioxidant effect: peroxisome proliferator-activated receptor alpha is associated with Cu2+, Zn2+-superoxide dismutase in the liver

Life Sci. 1998;63(2):135-44. doi: 10.1016/s0024-3205(98)00249-5.

Abstract

Administration of bezafibrate in rats significantly reduced the levels of plasma thiobarbituric acid-reactive substances (TBARS) in comparison with those obtained in rats fed a soy or lard chow. Moreover, an elevation of in vitro conjugated diene production and linoleic acid levels in the high-density lipoproteins and low-density lipoproteins induced by a soy or lard chow, was reduced by bezafibrate administration. In addition, the liver Cu2+, Zn2+-superoxide dismutase (SOD) gene expression showed a significant positive correlation with the liver peroxisome proliferator-activated receptor alpha (PPARalpha) mRNA level (R=0.769, p<0.0001). This unique characteristic of bezafibrate, which possesses both a hypolipidemic effect and antioxidant activity, may be beneficial in preventing vascular complications in hyperlipidemia.

MeSH terms

  • Acyl-CoA Oxidase
  • Animals
  • Antioxidants / pharmacology*
  • Bezafibrate / pharmacology*
  • Catalase / biosynthesis
  • Catalase / metabolism
  • Cholesterol / blood
  • Diet
  • Dietary Fats / administration & dosage
  • Fatty Acids / blood
  • Gene Expression Regulation, Enzymologic / drug effects
  • Hypolipidemic Agents / pharmacology*
  • Lipoproteins, HDL / analysis
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / analysis
  • Lipoproteins, LDL / blood
  • Liver / drug effects*
  • Liver / enzymology*
  • Liver / ultrastructure
  • Male
  • Oxidoreductases / biosynthesis
  • Oxidoreductases / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cytoplasmic and Nuclear / biosynthesis
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Soybeans
  • Superoxide Dismutase / biosynthesis*
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Transcription Factors / biosynthesis
  • Transcription Factors / physiology*

Substances

  • Antioxidants
  • Dietary Fats
  • Fatty Acids
  • Hypolipidemic Agents
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Receptors, Cytoplasmic and Nuclear
  • Thiobarbituric Acid Reactive Substances
  • Transcription Factors
  • Cholesterol
  • Oxidoreductases
  • Catalase
  • Superoxide Dismutase
  • Acyl-CoA Oxidase
  • Bezafibrate