Differential expression of insulin receptor tyrosine kinase inhibitor (fetuin) gene in a model of diet-induced obesity

Life Sci. 1998;63(2):145-53. doi: 10.1016/s0024-3205(98)00250-1.


The Differential Display technique has been used to identify differences in mRNA expression in adipose tissue after the introduction of a high fat diet to two strains of rat (OM and S5B/PI) that differ in their susceptibility to develop obesity on this diet. The insulin receptor tyrosine kinase inhibitor protein (fetuin) was shown to be differentially expressed in OM but not S5B/PI rats. This circulating protein may play a role in the development of peripheral insulin resistance associated with high fat diets.

MeSH terms

  • Animals
  • Base Sequence
  • DNA, Complementary / metabolism
  • Dietary Fats / administration & dosage*
  • Disease Models, Animal
  • Gene Expression Regulation*
  • Liver / metabolism
  • Male
  • Molecular Sequence Data
  • Obesity / etiology
  • Obesity / genetics*
  • Obesity / metabolism*
  • Phosphorylation
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Inbred Strains
  • Receptor, Insulin / antagonists & inhibitors*
  • Receptor, Insulin / metabolism
  • alpha-Fetoproteins / biosynthesis*
  • alpha-Fetoproteins / genetics


  • DNA, Complementary
  • Dietary Fats
  • RNA, Messenger
  • alpha-Fetoproteins
  • Receptor, Insulin