Differential expression of insulin receptor tyrosine kinase inhibitor (fetuin) gene in a model of diet-induced obesity

X Lin; H D Braymer; G A Bray; D A York

doi:10.1016/s0024-3205(98)00250-1

Differential expression of insulin receptor tyrosine kinase inhibitor (fetuin) gene in a model of diet-induced obesity

Life Sci. 1998;63(2):145-53. doi: 10.1016/s0024-3205(98)00250-1.

Authors

X Lin¹, H D Braymer, G A Bray, D A York

Affiliation

¹ Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA.

PMID: 9674949
DOI: 10.1016/s0024-3205(98)00250-1

Abstract

The Differential Display technique has been used to identify differences in mRNA expression in adipose tissue after the introduction of a high fat diet to two strains of rat (OM and S5B/PI) that differ in their susceptibility to develop obesity on this diet. The insulin receptor tyrosine kinase inhibitor protein (fetuin) was shown to be differentially expressed in OM but not S5B/PI rats. This circulating protein may play a role in the development of peripheral insulin resistance associated with high fat diets.

MeSH terms

Animals
Base Sequence
DNA, Complementary / metabolism
Dietary Fats / administration & dosage*
Disease Models, Animal
Gene Expression Regulation*
Liver / metabolism
Male
Molecular Sequence Data
Obesity / etiology
Obesity / genetics*
Obesity / metabolism*
Phosphorylation
RNA, Messenger / metabolism
Rats
Rats, Inbred Strains
Receptor, Insulin / antagonists & inhibitors*
Receptor, Insulin / metabolism
alpha-Fetoproteins / biosynthesis*
alpha-Fetoproteins / genetics

Substances

DNA, Complementary
Dietary Fats
RNA, Messenger
alpha-Fetoproteins
Receptor, Insulin