Multiple antimutagenesis mechanisms affect mutagenic activity and specificity of the base analog 6-N-hydroxylaminopurine in bacteria and yeast

Mutat Res. 1998 Jun 18;402(1-2):41-50. doi: 10.1016/s0027-5107(97)00280-7.


Base analog 6-N-hydroxylaminopurine is a potent mutagen in variety of prokaryotic and eukaryotic organisms. In the review, we discuss recent results of the studies of HAP mutagenic activity, genetic control and specificity in bacteria and yeast with the emphasis to the mechanisms protecting living cells from mutagenic and toxic effects of this base analog.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Amino Acid Sequence
  • Antimutagenic Agents / pharmacology*
  • Base Sequence
  • DNA, Bacterial / drug effects
  • DNA, Fungal / drug effects
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Molecular Sequence Data
  • Mutagens / pharmacology*
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / genetics
  • Sequence Homology, Amino Acid


  • Antimutagenic Agents
  • DNA, Bacterial
  • DNA, Fungal
  • Mutagens
  • 6-N-hydroxylaminopurine
  • Adenine