The pharmacodynamics of aminoglycosides

Clin Infect Dis. 1998 Jul;27(1):23-7. doi: 10.1086/514620.


Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity, established the foundation for once-daily aminoglycoside dosing regimens. This new approach to aminoglycoside dosing appears to be safe, efficacious, and cost-effective, resulting in its increasing popularity in clinical practice.

Publication types

  • Review

MeSH terms

  • Aminoglycosides
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / pharmacology*
  • Drug Administration Schedule
  • Drug Resistance, Microbial
  • Humans
  • Microbial Sensitivity Tests


  • Aminoglycosides
  • Anti-Bacterial Agents