Effect of black tea polyphenols on plasma lipids in cholesterol-fed rats

J Nutr Sci Vitaminol (Tokyo). 1998 Apr;44(2):337-42. doi: 10.3177/jnsv.44.337.

Abstract

The influence of black tea polyphenols on plasma lipid levels was investigated in rats fed a 15% lard and 1% cholesterol diet. The diet was supplemented with 1% black tea polyphenols extracted and condensed from black tea. Rats fed the lard-cholesterol diet showed an increase in plasma cholesterol and liver lipids compared to rats fed a basal diet. The supplementation of black tea polyphenols in this lard-cholesterol diet decreased the lipid levels in the plasma and increased the fecal excretion of total lipids and cholesterol. On the other hands, 1% supplementation of either instant black tea with a 20% polyphenol content of 0.2% supplementation of EGCg in the lard-cholesterol diet had no effect on plasma cholesterol and phospholipid levels. These results suggest that a high dose of black tea polyphenols exerts a hypocholesterolemic effect in cholesterol-fed rats.

MeSH terms

  • Animals
  • Anticholesteremic Agents*
  • Cholesterol / blood
  • Cholesterol / metabolism
  • Cholesterol, Dietary / administration & dosage*
  • Dietary Fats / administration & dosage
  • Flavonoids*
  • Lipid Metabolism
  • Lipids / blood*
  • Liver / anatomy & histology
  • Liver / metabolism
  • Male
  • Organ Size
  • Phenols / pharmacology*
  • Phospholipids / blood
  • Polymers / pharmacology*
  • Polyphenols
  • Rats
  • Rats, Wistar
  • Tea / chemistry*
  • Triglycerides / metabolism

Substances

  • Anticholesteremic Agents
  • Cholesterol, Dietary
  • Dietary Fats
  • Flavonoids
  • Lipids
  • Phenols
  • Phospholipids
  • Polymers
  • Polyphenols
  • Tea
  • Triglycerides
  • Cholesterol
  • lard