Virulence of enterohemorrhagic Escherichia coli: role of molecular crosstalk

Trends Microbiol. 1998 Jun;6(6):228-33. doi: 10.1016/s0966-842x(98)01282-7.


Many bacterial exotoxins, originally defined by cytopathic effects, may also possess additional biological activities. The capacity of exotoxins to elicit the synthesis and secretion of pro- or anti-inflammatory cytokines may be as important as their direct toxic effects in pathogenesis. One example of such 'molecular crosstalk' occurs between Shiga toxins and the cytokines made in response to these toxins during the development of disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacterial Toxins / metabolism
  • Cytokines / physiology*
  • Enterocolitis / microbiology
  • Enterotoxins / metabolism
  • Escherichia coli / metabolism
  • Escherichia coli / pathogenicity*
  • Escherichia coli O157 / metabolism
  • Escherichia coli O157 / pathogenicity*
  • Hemolytic-Uremic Syndrome / microbiology
  • Humans
  • Shiga Toxins
  • Signal Transduction*
  • Virulence


  • Bacterial Toxins
  • Cytokines
  • Enterotoxins
  • Shiga Toxins