Influence of interleukin-1beta on exploratory behaviors, plasma ACTH, corticosterone, and central biogenic amines in mice

Psychopharmacology (Berl). 1998 Jun;137(4):351-61. doi: 10.1007/s002130050630.


Systemic administration of interleukin-1beta (IL-1beta) promoted behavioral changes in an open-field exploratory test. In particular, while the cytokine suppressed locomotor activities, these behaviors were not particularly sensitive to dosage differences. In contrast, dose-dependent biphasic variations that varied over time were evident with respect to the exploration of a novel container. Within this paradigm, the behavioral changes did not appear to be related to neophobia. In addition, despite the marked effects of IL-1beta on exploratory and locomotor behaviors, habituation/exploration in a free-running spontaneous alternation task was unaffected by the cytokine. In addition to the behavioral variations, IL-1beta dose-dependently increased plasma ACTH and corticosterone concentrations, and also induced several central monoamine alterations. In particular, IL-1beta increased the utilization of norepinephrine (NE) within the paraventricular nucleus, arcuate nucleus/median eminence, locus coeruleus, and prefrontal cortex, while the turnover of dopamine (DA) was evident in the arcuate nucleus/median eminence. It is suggested that although systemic IL-1beta treatment induces some stress-like effects, the profile of central neurochemical changes induced by the cytokine can be distinguished from psychological or processive types of stressors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenocorticotropic Hormone / blood*
  • Animals
  • Biogenic Amines / blood*
  • Brain Chemistry / drug effects*
  • Corticosterone / blood*
  • Dose-Response Relationship, Drug
  • Exploratory Behavior / drug effects*
  • Interleukin-1 / pharmacology*
  • Male
  • Mice
  • Motor Activity / drug effects


  • Biogenic Amines
  • Interleukin-1
  • Adrenocorticotropic Hormone
  • Corticosterone