[Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent]

Minerva Ginecol. 1998 May;50(5):207-11.
[Article in Italian]


Background: Menopausal symptoms include hot flushes, insomnia, nocturnal sweating, dizziness, headaches and palpitations. These symptoms reflect adaptation of the body to estrogen deprivation which affects various central neurotransmitters.

Methods: In this study, the efficacy has been tested of a plant product based on extracts of the leaves of Salvia officinalis (sage) and Medicago sativa (alfalfa) in the treatment of hot flushes in 30 menopausal women with these symptoms.

Results: Hot flushes and night sweating completely disappeared in 20 women: four women showed good improvement and the other six showed a reduction in symptoms. GnRH and TRH tests were performed in 8 women to evaluate TSH and Prl responses before and after 3 months of therapy. The plants product induced a significant increase in Prl and TSH response to TRH. Basal levels of estradiol, LH, FSH, Prl and TSH were unchanged.

Conclusions: The product seams to have a central slight antidopaminergic action without side effects and is an effective agent in the treatment of menopausal symptoms.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • English Abstract

MeSH terms

  • Dizziness / drug therapy
  • Dizziness / etiology*
  • Female
  • Headache / drug therapy
  • Headache / etiology*
  • Humans
  • Hyperhidrosis / drug therapy
  • Hyperhidrosis / etiology*
  • Menopause*
  • Middle Aged
  • Phytotherapy*
  • Sleep Initiation and Maintenance Disorders / drug therapy
  • Sleep Initiation and Maintenance Disorders / etiology
  • Treatment Outcome