Abstract
Quantitative 2-dimensional and Doppler echocardiography was used to assess the longitudinal effects of angiotensin-converting enzyme inhibition in asymptomatic patients with chronic, severe mitral regurgitation due to mitral valve prolapse. Over a 6-month period, angiotensin-converting enzyme inhibition therapy resulted in significant reductions in left ventricular volumes and mass in association with a minor reduction in regurgitant fraction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
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Echocardiography, Doppler / methods
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Enalapril / therapeutic use*
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Exercise Test
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Female
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Humans
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Hypertrophy, Left Ventricular / diagnostic imaging
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Hypertrophy, Left Ventricular / drug therapy*
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Male
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Middle Aged
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Mitral Valve Insufficiency / diagnostic imaging
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Mitral Valve Insufficiency / drug therapy*
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Mitral Valve Insufficiency / etiology
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Mitral Valve Prolapse / complications*
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Mitral Valve Prolapse / diagnostic imaging
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Time Factors
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Treatment Outcome
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Enalapril