Expression of receptors for neuregulins, ErbB2, ErbB3 and ErbB4, in developing mouse cerebellum

Neurosci Res. 1998 Apr;30(4):351-4. doi: 10.1016/s0168-0102(98)00013-3.

Abstract

We have examined the expression of ErbB2, ErbB3 and ErbB4 in developing mouse cerebellum. ErbB2, ErbB3 and ErbB4 were all expressed in granule cells during cerebellar development. However, the expression pattern for each ErbB receptor changed with the developmental stage. Variations of signal transduction pathway through combinations of these ErbB receptors might have important roles in controlling cerebellar postnatal development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blotting, Western
  • Cerebellum / chemistry*
  • Cerebellum / cytology
  • Cerebellum / growth & development
  • ErbB Receptors / genetics*
  • Gene Expression Regulation, Developmental
  • Glycoproteins / genetics*
  • In Situ Hybridization
  • Mice
  • Nerve Fibers / chemistry
  • Neuregulins
  • Proto-Oncogene Proteins / genetics*
  • RNA, Messenger / analysis
  • Receptor, ErbB-2 / genetics*
  • Receptor, ErbB-3
  • Receptor, ErbB-4
  • Signal Transduction / physiology
  • Synapses / chemistry

Substances

  • Glycoproteins
  • Neuregulins
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • ErbB Receptors
  • Erbb4 protein, mouse
  • Receptor, ErbB-2
  • Receptor, ErbB-3
  • Receptor, ErbB-4