Abstract
In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the lesion but also in the substantia nigra pars reticulata (SNr) ipsilateral to the lesion. Thus, hemispheric asymmetries in FLI were induced by methamphetamine in the medial striatum and the SNr in the 6-OHDA model of turning which may be related to the altered function of glutamatergic transmission.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dizocilpine Maleate / pharmacology
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Excitatory Amino Acid Antagonists / pharmacology
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Female
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Methamphetamine / pharmacology*
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Nerve Fibers / chemistry
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Nerve Fibers / drug effects
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Nerve Fibers / enzymology
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Oxidopamine
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Proto-Oncogene Proteins c-fos / analysis
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Proto-Oncogene Proteins c-fos / biosynthesis*
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Rats
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Rats, Wistar
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Substantia Nigra / chemistry
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Substantia Nigra / metabolism*
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Sympatholytics
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Sympathomimetics / pharmacology*
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Tyrosine 3-Monooxygenase / analysis
Substances
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Excitatory Amino Acid Antagonists
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Proto-Oncogene Proteins c-fos
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Sympatholytics
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Sympathomimetics
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Methamphetamine
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Dizocilpine Maleate
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Oxidopamine
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Tyrosine 3-Monooxygenase