Posterior capsule opacification and neodymium: YAG capsulotomy with heparin-surface-modified intraocular lenses

J Cataract Refract Surg. 1998 Jul;24(7):940-4. doi: 10.1016/s0886-3350(98)80047-3.


Purpose: To compare the effect of heparin-surface-modified (HSM) and conventional unmodified poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) on the formation of posterior capsule opacification (PCO).

Setting: Department of Ophthalmology, Vejle Hospital, Denmark.

Methods: This prospective, randomized, double-blind study comprised 250 eyes of 246 patients who had uneventful extracapsular cataract extraction in otherwise healthy eyes with implantation of a biconvex IOL or a convex-plano lens with a continuous laser ridge. Patients were examined once a year for 3 years, at which time the degree of PCO was recorded. A neodymium:YAG laser capsulotomy was performed if certain criteria were met.

Results: The incidence of PCO was statistically significantly higher in eyes with an HSM convex-plano laser-ridge IOL than in those with an unmodified convex-plano lens (P < .005). There were no significant differences between any other groups.

Conclusion: The incidence of PCO was higher in eyes with an HSM convex-plano IOL with a laser ridge.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Capsulorhexis
  • Cataract / etiology*
  • Cataract / pathology
  • Double-Blind Method
  • Heparin / adverse effects*
  • Humans
  • Laser Therapy*
  • Lens Capsule, Crystalline / pathology*
  • Lens Capsule, Crystalline / surgery
  • Lens Implantation, Intraocular
  • Lenses, Intraocular / adverse effects*
  • Polymethyl Methacrylate
  • Prospective Studies


  • Heparin
  • Polymethyl Methacrylate