Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine

Vaccine. 1998 Jul;16(11-12):1131-7. doi: 10.1016/s0264-410x(98)80110-2.


The current human whole-cell vaccine is ineffective against pneumonic plague caused by typical F1 capsule positive (F1+) strains of Yersinia pestis. The authors found this vaccine to also be ineffective against F1-negative (F1-) Y. pestis strains, which have been isolated from a human case and from rodents. For these reasons, the authors developed a recombinant vaccine composed of a fusion protein of F1 with a second protective immunogen, V antigen. This vaccine protected experimental mice against pneumonic as well as bubonic plague produced by either an F1+ or F1- strain of Y. pestis, gave better protection than F1 or V alone against the F1+ strain, and may provide the basis for an improved human plague vaccine.

MeSH terms

  • Aerosols
  • Animals
  • Antigens, Bacterial*
  • Bacterial Capsules / immunology*
  • Female
  • Humans
  • Injections, Subcutaneous
  • Mice
  • Molecular Weight
  • Plague / prevention & control*
  • Recombinant Fusion Proteins / immunology*
  • Species Specificity
  • Vaccines, Synthetic*


  • Aerosols
  • Antigens, Bacterial
  • Recombinant Fusion Proteins
  • Vaccines, Synthetic