Frequency of the SCID gene among Arabian horses in the USA

Anim Genet. 1998 Feb;29(1):41-2. doi: 10.1046/j.1365-2052.1998.00237.x.


Severe combined immunodeficiency disease (SCID) of horses is an autosomal, recessive hereditary disease occurring among Arabian horses. The genetic defect responsible for this disease was recently identified as a 5-basepair deletion in the gene encoding DNA-protein kinase catalytic subunit (DNA-PKcs). Horses with one copy of the gene appear normal, while horses with two copies of the gene manifest the disease. The present report describes a PCR-based test for detection of the gene defect and the results from testing 250 randomly selected Arabian horses. The frequency of SCID gene carriers was 8.4% (21/250). Based on the gene frequency reported here, the authors would expect 0.18% (1 out of 567) of Arabian foals to be affected with SCID based on a random breeding population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breeding
  • DNA Primers
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins*
  • Electrophoresis, Polyacrylamide Gel / veterinary
  • Gene Frequency / genetics*
  • Horse Diseases / diagnosis
  • Horse Diseases / genetics*
  • Horses
  • Male
  • Polymerase Chain Reaction / veterinary
  • Protein Serine-Threonine Kinases / genetics*
  • Severe Combined Immunodeficiency / diagnosis
  • Severe Combined Immunodeficiency / genetics
  • Severe Combined Immunodeficiency / veterinary*
  • United States


  • DNA Primers
  • DNA-Binding Proteins
  • DNA-Activated Protein Kinase
  • Protein Serine-Threonine Kinases