A case of alternating hemiplegia of childhood with cerebellar atrophy

Pediatr Neurol. 1998 Jul;19(1):65-8. doi: 10.1016/s0887-8994(98)00016-2.


A case of alternating hemiplegia of childhood is reported. Tonic fits and generalized tonic-clonic seizures developed during her infancy. Frequent twitching and apneic seizures appeared at 16 years of age. Zonisamide transiently suppressed the tonic, twitching and apneic seizures, as well as the facial and neck dystonia. Cranial computed tomography and magnetic resonance imaging revealed progressive vermian atrophy. Cerebellar dysfunction may play a role in the clinical features of some patients with alternating hemiplegia of childhood.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Atrophy
  • Cerebellum / pathology*
  • Epilepsy, Tonic-Clonic / diagnosis
  • Epilepsy, Tonic-Clonic / physiopathology
  • Female
  • Follow-Up Studies
  • Functional Laterality / physiology*
  • Hemiplegia / etiology*
  • Hemiplegia / physiopathology
  • Humans
  • Magnetic Resonance Imaging
  • Neurologic Examination
  • Tomography, X-Ray Computed