Clinicopathologic correlations of surgically excised type 1 and type 2 submacular choroidal neovascular membranes

Am J Ophthalmol. 1998 Jul;126(1):59-69. doi: 10.1016/s0002-9394(98)00145-7.


Purpose: To correlate the histologic and clinical classification of type 1 (subretinal pigment epithelium) and type 2 (subsensory retina) choroidal neovascularization.

Methods: Ten eyes of 10 patients with surgically excised choroidal neovascularization that were routinely processed and could be histologically classified as having a type 1 or type 2 configuration were studied. The patients were clinically classified as having type 1 or type 2 choroidal neovascularization according to preoperative fundus appearance of both eyes and patient age. The histologic and clinical classifications were made in a masked fashion, and the results were compared.

Results: The histologic classification was type 1 and type 2 for three and seven specimens, respectively. The clinical classification matched the histologic classification in nine of 10 cases. Clinical fundus characteristics that distinguished type 2 choroidal neovascularization included a subretinal pigmented halo or pigmented plaque in the area of the choroidal neovascularization and sharply defined borders. Patients with type 1 membranes were on average older (76 years) than patients with type 2 membranes (53 years).

Conclusions: It is generally possible to clinically ascertain by clinical fundus appearance and age of a patient whether subfoveal choroidal neovascularization represents a type 1 or type 2 configuration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Choroid / blood supply*
  • Choroid / pathology
  • Female
  • Fundus Oculi
  • Humans
  • Macula Lutea*
  • Male
  • Membranes / pathology
  • Middle Aged
  • Neovascularization, Pathologic / classification*
  • Neovascularization, Pathologic / pathology*
  • Neovascularization, Pathologic / surgery
  • Pigment Epithelium of Eye / pathology
  • Retina / pathology