Lancet. 1998 Jul 18;352(9123):220-8. doi: 10.1016/S0140-6736(97)12169-9.


Disorders of serum sodium are both the most common and probably most the poorly understood electrolyte disorders in clinical medicine. In the past few years increased knowledge about the non-osmotic release of vasopressin and the cloning of vasopressin receptors and of vasopressin-regulated water channels (AQP2) has enhanced our understanding of these disorders. Also controversies surrounding the treatment of hyponatraemic patients have led to well-accepted therapeutic guidelines.

Publication types

  • Review

MeSH terms

  • Diabetes Insipidus*
  • Humans
  • Hypernatremia*
  • Hyponatremia*
  • Osmolar Concentration
  • Sodium* / blood
  • Sodium* / physiology


  • Sodium