A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity

Trends Neurosci. 1998 Jul;21(7):273-8. doi: 10.1016/s0166-2236(97)01205-8.


The current view of the role of GABAergic interneurones in cortical-network function has shifted from one of merely dampening neuronal activity to that of an active role in information processing. In this review, we explore a potential role of hippocampal GABAergic interneurones in providing spatial and temporal conditions for modifications of synaptic weights during hippocampus-dependent memory processes. We argue that knowledge of spatiotemporal activity patterns in distinct classes of interneurone is essential to understanding the cellular mechanisms underlying learning and memory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Electroencephalography
  • Hippocampus / physiology*
  • Hippocampus / ultrastructure
  • Humans
  • Memory / physiology*
  • Mental Processes / classification
  • Mental Processes / physiology
  • Models, Neurological
  • Neuronal Plasticity / physiology*
  • Neurons / classification
  • Neurons / ultrastructure
  • Receptors, GABA / physiology
  • Synaptic Transmission / physiology*
  • gamma-Aminobutyric Acid / biosynthesis*


  • Receptors, GABA
  • gamma-Aminobutyric Acid