The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review)

Oncol Rep. Sep-Oct 1998;5(5):1013-24. doi: 10.3892/or.5.5.1013.

Abstract

The protein product of c-met proto-oncogene, Met, is a tyrosine kinase receptor for the hepatocyte growth factor (HGF), also known as the scatter factor (SF). HGF/SF-Met signaling has multifunctional effects on mammalian cells. These include stimulation or inhibition of cellular proliferation, promotion of cell movement, invasion into extracellular matrix, and induction of glandular/tubular morphogenesis by epithelial cells. There is a substantial body of experimental evidence that supports the oncogenic role of HGF/SF-Met signaling pathways. This is putatively mediated by autocrine or paracrine mechanisms that promote tumor cell growth, invasion and angiogenesis. We review the evidence that HGF/SF and Met receptor play significant roles in the pathogenesis and biology of human cancers.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic
  • Hepatocyte Growth Factor / biosynthesis
  • Hepatocyte Growth Factor / physiology*
  • Humans
  • Neoplasms / blood supply
  • Neoplasms / pathology
  • Neoplasms / physiopathology*
  • Neovascularization, Pathologic
  • Proto-Oncogene Proteins c-met / biosynthesis
  • Proto-Oncogene Proteins c-met / physiology*
  • Signal Transduction

Substances

  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-met