Twins may have a special capacity for supporting each other (co-regulation) because of their common intrauterine experiences. Co-regulatory activities observed in preterm twins during co-bedding include moving closer, touching, holding, hugging, rooting, sucking on each other, smiling, being awake at the same time, and decreased need for ambient temperature support. This simple clinical strategy of co-bedding twins may be a significant innovation for supporting preterm and full-term twins during their transition to extrauterine life.