Identification of LFA-1 as a Candidate Autoantigen in Treatment-Resistant Lyme Arthritis

Science. 1998 Jul 31;281(5377):703-6. doi: 10.1126/science.281.5377.703.

Abstract

Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Algorithms
  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Antigens, Surface / immunology
  • Antigens, Surface / metabolism
  • Arthritis, Reactive / drug therapy
  • Arthritis, Reactive / immunology*
  • Autoantigens / immunology*
  • Autoimmune Diseases / immunology*
  • Bacterial Outer Membrane Proteins / immunology
  • Bacterial Outer Membrane Proteins / metabolism
  • Bacterial Vaccines
  • Borrelia burgdorferi Group / immunology
  • Child
  • Cross Reactions
  • Female
  • HLA-DR Antigens / genetics
  • HLA-DR Antigens / immunology
  • HLA-DR Antigens / metabolism
  • HLA-DRB1 Chains
  • Humans
  • Immunodominant Epitopes
  • Lipoproteins*
  • Lyme Disease / drug therapy
  • Lyme Disease / immunology*
  • Lymphocyte Function-Associated Antigen-1 / chemistry
  • Lymphocyte Function-Associated Antigen-1 / immunology*
  • Lymphocyte Function-Associated Antigen-1 / metabolism
  • Male
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • Synovial Fluid / immunology
  • T-Lymphocytes, Helper-Inducer / immunology

Substances

  • Antigens, Surface
  • Autoantigens
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • HLA-DRB1*04:01 antigen
  • Immunodominant Epitopes
  • Lipoproteins
  • Lymphocyte Function-Associated Antigen-1
  • OspA protein