Subpopulations of cortical GABAergic interneurons differ by their expression of D1 and D2 dopamine receptor subtypes

Brain Res Mol Brain Res. 1998 Jul 15;58(1-2):231-6. doi: 10.1016/s0169-328x(98)00118-1.


D1 and D2 receptors have been described in different populations of efferent pyramidal neurons of the rat frontal cortex. Combined in situ hybridization and immunocytochemistry show here that these two subtypes are expressed in cortical GABAergic interneurons, with D1 and D2 mainly found in a subpopulation containing parvalbumin, whereas only 10% of the calbindin neurons express D1 receptors. These data indicate that various DA agonists may influence inhibitory circuits by distinct dopamine receptor subtypes.

MeSH terms

  • Animals
  • Calbindins
  • Cerebral Cortex / cytology
  • Cerebral Cortex / metabolism*
  • Interneurons / classification
  • Interneurons / cytology
  • Interneurons / metabolism*
  • Male
  • Parvalbumins / analysis
  • RNA, Messenger / biosynthesis
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1 / biosynthesis
  • Receptors, Dopamine D1 / genetics*
  • Receptors, Dopamine D2 / biosynthesis
  • Receptors, Dopamine D2 / genetics*
  • S100 Calcium Binding Protein G / analysis
  • Transcription, Genetic
  • gamma-Aminobutyric Acid / analysis*


  • Calbindins
  • Parvalbumins
  • RNA, Messenger
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • S100 Calcium Binding Protein G
  • gamma-Aminobutyric Acid