Age- and temperature-dependent effects of opioids on medulla oblongata respiratory activity: an in vitro study in newborn rat

Brain Res. 1998 Aug 3;800(2):308-11. doi: 10.1016/s0006-8993(98)00476-4.

Abstract

Influences of post-natal age (P0-P4) and temperature (22.5 degrees-31.5 degrees C) on the action(s) of opioids on respiratory activities from neonatal rat brainstem-spinal cord preparations were examined in this study. A temperature-dependent mu-opioid receptor effect on respiration was found. In addition, the effect of morphine increased with postnatal age (P0-P4). Hence, age and temperature must be taken into account when performing studies on medullary respiration-related structures using the neonatal rat brainstem-spinal cord preparation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer / pharmacology
  • Age Factors
  • Analgesics / pharmacology
  • Analgesics, Non-Narcotic / pharmacology
  • Analgesics, Opioid / pharmacology*
  • Animals
  • Animals, Newborn
  • Dose-Response Relationship, Drug
  • Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
  • Enkephalin, D-Penicillamine (2,5)-
  • Enkephalins / pharmacology
  • In Vitro Techniques
  • Medulla Oblongata / drug effects*
  • Medulla Oblongata / physiology*
  • Morphine / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Respiration / physiology*
  • Spinal Cord / physiology
  • Temperature

Substances

  • Analgesics
  • Analgesics, Non-Narcotic
  • Analgesics, Opioid
  • Enkephalins
  • Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
  • 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
  • Morphine
  • Enkephalin, D-Penicillamine (2,5)-