Pallidotomy for generalized dystonia

Mov Disord. 1998 Jul;13(4):693-8. doi: 10.1002/mds.870130415.


We systematically evaluated the efficacy of both unilateral and bilateral stereotactic pallidotomy in eight patients with generalized dystonia. Six patients had a marked improvement in dystonic movements and motor function; the other two patients also benefited from the procedure but to a lesser extent. The severity of dystonia was assessed before and after surgery by the Burke-Marsden-Fahn Dystonia Scale (BMFDS), the Unified Dystonia Rating Scale (UDRS), and the Activity of Daily Living Scale (ADL). The BMFDS scores decreased by 59.0%, UDRS by 62.5%, and ADL by 47.8% postoperatively. Adverse events were limited to a transient weakness in one patient. We conclude that pallidotomy is a safe and effective treatment in medically refractory cases of generalized dystonia.

Publication types

  • Case Reports

MeSH terms

  • Activities of Daily Living / classification
  • Adolescent
  • Adult
  • Brain Mapping
  • Child
  • Dominance, Cerebral / physiology
  • Dystonia / diagnosis
  • Dystonia / physiopathology
  • Dystonia / surgery*
  • Female
  • Globus Pallidus / physiopathology
  • Globus Pallidus / surgery*
  • Humans
  • Male
  • Middle Aged
  • Motor Skills / physiology
  • Neurologic Examination
  • Postoperative Complications / diagnosis
  • Stereotaxic Techniques*
  • Treatment Outcome