H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels

Curr Opin Neurobiol. 1998 Jun;8(3):418-24. doi: 10.1016/s0959-4388(98)80070-6.


Novel members of the amiloride-sensitive Na+ channel/ degenerin family of ion channels were discovered recently. With the cloning of four mammalian H(+)-gated cation channel subunits, the first members of a novel class of ligand-gated cation channels were identified. H(+)-gated cation channel subunits are expressed in the central and peripheral nervous system. In sensory neurones, they are thought to be involved in the perception of pain that accompanies tissue acidosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cations / metabolism
  • Degenerin Sodium Channels
  • Epithelial Sodium Channels
  • Ion Channel Gating / physiology*
  • Ion Channels / genetics*
  • Ion Channels / metabolism
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / metabolism
  • Neurons / chemistry*
  • Neurons / physiology
  • Protons*
  • Sequence Homology, Amino Acid
  • Signal Transduction / physiology
  • Sodium Channels / genetics*
  • Sodium Channels / metabolism


  • Cations
  • Degenerin Sodium Channels
  • Epithelial Sodium Channels
  • Ion Channels
  • Nerve Tissue Proteins
  • Protons
  • Sodium Channels