Activation and repression in the nervous system

Curr Opin Neurobiol. 1998 Jun;8(3):413-7. doi: 10.1016/s0959-4388(98)80069-x.


The mechanisms underlying transcriptional activation and repression have become much clearer. Recent evidence suggests that transcription factors that do not bind DNA directly, the co-activators and co-repressors, mediate a large number of cell signaling events. Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated.

Publication types

  • Review

MeSH terms

  • CREB-Binding Protein
  • Gene Expression Regulation*
  • Nervous System Physiological Phenomena*
  • Nuclear Proteins / genetics
  • Signal Transduction / genetics*
  • Trans-Activators / genetics
  • Transcriptional Activation / physiology*


  • Nuclear Proteins
  • Trans-Activators
  • CREB-Binding Protein