Generalized linear least squares method for fast generation of myocardial blood flow parametric images with N-13 ammonia PET

IEEE Trans Med Imaging. 1998 Apr;17(2):236-43. doi: 10.1109/42.700735.

Abstract

In this paper, we developed and tested strategies for estimating myocardial blood flow (MBF) and generating MBF parametric images using positron emission tomography (PET), N-13 ammonia, and the generalized linear least square (GLLS) method. GLLS was generalized to the general linear compartment model, modified for the correction of spillover, validated using simulated N-13 ammonia data, and examined using PET data from several patient studies. In comparison to the standard model-fitting procedure, the GLLS method provided similar accuracy and superior computational speed.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Algorithms
  • Ammonia*
  • Computer Simulation
  • Coronary Circulation / physiology*
  • Coronary Disease / physiopathology
  • Coronary Disease / surgery
  • Heart / diagnostic imaging*
  • Humans
  • Image Enhancement / methods
  • Internal Mammary-Coronary Artery Anastomosis
  • Least-Squares Analysis
  • Linear Models
  • Male
  • Models, Cardiovascular
  • Nitrogen Radioisotopes*
  • Radiopharmaceuticals*
  • Reproducibility of Results
  • Time Factors
  • Tomography, Emission-Computed* / methods
  • Tomography, Emission-Computed* / statistics & numerical data

Substances

  • Nitrogen Radioisotopes
  • Radiopharmaceuticals
  • Ammonia