A new model of renal microvascular injury

Curr Opin Nephrol Hypertens. 1998 Jul;7(4):457-62. doi: 10.1097/00041552-199807000-00018.


The vascular endothelial injury with its consequent activation is actively involved in inflammation and promotion of a procoagulant state, which are likely to be of major importance in the pathogenesis of various disorders, including renal thrombotic microangiopathy. This study briefly reviews the consequences of glomerular endothelial cell injury or activation, as shown by recent experimental data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acute Kidney Injury / physiopathology*
  • Animals
  • Disease Models, Animal*
  • Endothelium, Vascular / pathology*
  • Endothelium, Vascular / physiopathology
  • Humans
  • Kidney Glomerulus / blood supply*
  • Kidney Glomerulus / pathology
  • Microcirculation / physiopathology