[The protective action of ellagic acid in experimental myocarditis]

Eksp Klin Farmakol. May-Jun 1998;61(3):32-4.
[Article in Russian]

Abstract

The article presents the material on the study of the cardioprotective effect of ellagic acid on a model of neoepinephrine myocarditis in rats. In doses of 0.5-1 mg/kg ellagic acid causes a marked antioxidant effect. Restores the disturbed myocardial functions. The reference-agent vitamin E (50 mg/kg) yields to ellagic acid as a cardioprotector. The effect of 0.5 mg/kg of ellagic acid was more stable than that of a 1 mg/kg dose. The cardioprotective activity of the drugs under study was determined according to the POL parameters in a myocardial homogenate and blood serum and according to the EEG parameters and the degree of cardiomyocyte cytolysis.

Publication types

  • Comparative Study

MeSH terms

  • Adrenergic beta-Agonists
  • Animals
  • Antioxidants / therapeutic use*
  • Cardiovascular Agents / therapeutic use*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Ellagic Acid / therapeutic use*
  • Isoproterenol
  • Myocarditis / chemically induced
  • Myocarditis / drug therapy*
  • Myocarditis / metabolism
  • Myocarditis / physiopathology
  • Rats
  • Tocopherols
  • Vitamin E / analogs & derivatives
  • Vitamin E / therapeutic use
  • alpha-Tocopherol* / analogs & derivatives*

Substances

  • Adrenergic beta-Agonists
  • Antioxidants
  • Cardiovascular Agents
  • Vitamin E
  • Ellagic Acid
  • alpha-Tocopherol
  • Isoproterenol
  • Tocopherols