Effect of gastrointestinal hormone infusions of lower oesophageal competence of rhesus monkeys

Br J Surg. 1978 Jul;65(7):499-504. doi: 10.1002/bjs.1800650716.

Abstract

The lower oesophageal high pressure zone (HPZ) was studied in 5 non-refluxing and 3 refluxing Rhesus monkeys. The changes in HPZ and reflux status in response to infusion of various doses of secretin, cholecystokinin and glucagon were measured in all animals, and, in the 5 non-refluxing monkeys, after oesophagogastrectomy with replacement of the lower oesophagus by a stomach tube. All three hormones consistently produced a transient decrease in the HPZ pressure. The only change in response following oesophagagastrectomy and gastric tube replacement was a significant delay in the response to each hormone. Neither hormone infusion nor operation altered gastro-oesophageal reflux status. It appears that lower oesophageal competence in primates is more dependent on the presence of narrow, muscular, intra-abdominal tube than on a specialized segment of the lower oesophagus.

MeSH terms

  • Animals
  • Cholecystokinin / pharmacology*
  • Esophagogastric Junction / drug effects
  • Esophagogastric Junction / physiology*
  • Esophagogastric Junction / physiopathology
  • Esophagus / surgery
  • Gastrectomy
  • Gastroesophageal Reflux / physiopathology
  • Glucagon / pharmacology*
  • Haplorhini
  • Macaca mulatta
  • Male
  • Pressure
  • Secretin / pharmacology*
  • Time Factors

Substances

  • Secretin
  • Glucagon
  • Cholecystokinin