Mobile elements and disease

Curr Opin Genet Dev. 1998 Jun;8(3):343-50. doi: 10.1016/s0959-437x(98)80092-0.


A substantial fraction of mammalian genomes is composed of mobile elements and their remnants. Recent insertions of LTR-retrotransposons, non-LTR retrotransposons, and non-autonomous retrotransposons have caused disease frequently in mice, but infrequently in humans. Although many of these elements are defective, a number of mammalian non-LTR retrotransposons of the L1 type are capable of autonomous retrotransposition. The mechanism by which they retrotranspose and in turn aide the retrotransposition of non-autonomous elements is being elucidated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease / etiology*
  • Humans
  • Interspersed Repetitive Sequences / genetics*
  • Mutagenesis, Insertional