Oligonucleotide libraries--variatio delectat

Curr Opin Chem Biol. 1998 Jun;2(3):320-7. doi: 10.1016/s1367-5931(98)80004-5.


In vitro selection of combinatorial nucleic acid libraries leads to specific target-binding molecules--RNA, single stranded DNA, modified RNA or modified DNA, commonly designated as aptamers--and to novel catalytic nucleic acids. The current state of aptamer and ribozyme technology is such that it establishes itself as a means of obtaining useful tools for molecular biology, diagnostics, molecular medicine and bio-organic chemistry.

Publication types

  • Review

MeSH terms

  • Base Sequence*
  • Binding Sites
  • Catalysis
  • DNA / chemistry*
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Oligonucleotides*
  • RNA / chemistry*
  • RNA, Catalytic / chemistry


  • Oligonucleotides
  • RNA, Catalytic
  • RNA
  • DNA