Clinically significant cytochrome P-450 drug interactions--a comment

Pharmacotherapy. 1998 Jul-Aug;18(4):890-1; discussion 892-3.

Authors

N F Ford¹, D S Sonnichsen

Affiliation

¹ Division of Clinical Pharmacology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA.

PMID: 9692671

No abstract available

Publication types

Comment

MeSH terms

Cytochrome P-450 CYP1A2 / metabolism
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 CYP2D6 / metabolism
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System / metabolism*
Drug Interactions
Enzyme Inhibitors / pharmacology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / metabolism
Isoenzymes / antagonists & inhibitors
Isoenzymes / metabolism*
Mixed Function Oxygenases / antagonists & inhibitors
Mixed Function Oxygenases / metabolism*
Pravastatin / metabolism

Substances

Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Isoenzymes
Cytochrome P-450 Enzyme System
Mixed Function Oxygenases
CYP3A protein, human
Cytochrome P-450 CYP1A2
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Pravastatin