Growth-hormone-receptor and cytokine-receptor-family signaling

Eur J Biochem. 1998 Jul 1;255(1):1-11. doi: 10.1046/j.1432-1327.1998.2550001.x.


Structure of growth-hormone receptor and the class I type of cytokine receptors: common structural features; cytokine-receptor isoforms; oligomerization of receptor components initiates cytokine signalling. Role of the Jak kinases in mediating specific functions of growth-hormone receptor and cytokine receptors. Role of signal transducer and activator of transcription (Stat) proteins in growth hormone and cytokine functions. Other pathways activated by cytokine receptors: the mitogen-activated protein kinase pathway; insulin-receptor substrates 1 and 2 and phosphatidylinositol-3-kinase pathways; the Src pathways and other tyrosine kinase pathways; the phospholipase C/protein kinase C/Ca2+ pathways. Regulation of growth-hormone receptor and cytokine receptor signaling: binding sites, internalization and ubiquitination; phosphatases and Janus kinase/Stat inhibitors. Conclusions and future prospects.

Publication types

  • Review

MeSH terms

  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation
  • Models, Biological
  • Protein-Tyrosine Kinases / metabolism*
  • Receptors, Cytokine / metabolism*
  • Receptors, Somatotropin / metabolism*
  • Signal Transduction
  • Trans-Activators / metabolism*


  • DNA-Binding Proteins
  • Receptors, Cytokine
  • Receptors, Somatotropin
  • Trans-Activators
  • Protein-Tyrosine Kinases