Budesonide in the treatment of collagenous colitis

Digestion. Jul-Aug 1998;59(4):364-6. doi: 10.1159/000007516.

Abstract

Collagenous colitis is characterized by watery diarrhea and inflammatory infiltration associated with a subepithelial collagen deposit on colonic biopsies despite a normal or subnormal endoscopic appearance. We here describe 5 patients treated with the locally active steroid budesonide. Complete and partial response was observed in 3 and 2 patients, respectively. Budesonide thus seems to be of therapeutic benefit in collagenous colitis. Prospective randomized long-term studies are needed to support this hypothesis.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents / therapeutic use*
  • Biopsy
  • Budesonide / therapeutic use*
  • Colitis / complications
  • Colitis / drug therapy*
  • Colitis / pathology
  • Collagen / metabolism*
  • Collagen Diseases / complications
  • Collagen Diseases / drug therapy*
  • Collagen Diseases / pathology
  • Colon / metabolism
  • Colon / pathology
  • Colonoscopy
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged

Substances

  • Anti-Inflammatory Agents
  • Budesonide
  • Collagen