Quantitative analysis of hyaluronan in the synovial tissues of patients with joint disorders

Clin Rheumatol. 1998;17(3):261-2. doi: 10.1007/BF01451063.


Quantitative analysis of hyaluronan (hyaluronic acid; HA) in the synovial tissues of patients with joint disorders were performed. HA was found not only in the synovial intimal cells and matrices, but also especially in the alveolar lymphoid follicles and connective tissues surrounding blood vessels in the inflammatory granular synovium which formed the pannus. HA levels in the synovium of patients with rheumatoid arthritis (RA) (459.0+/-66.2 microg/g) where shown to be higher than those in patients with osteoarthritis (246.9+/-34.8 microg/g) and traumatic injury (227.7+/-35.4 microg/g). It follows from the present findings, HA in the synovium might contribute to the high amounts of serum levels of HA in patients with rheumatoid arthritis.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / diagnosis
  • Arthritis, Rheumatoid / metabolism*
  • Diagnosis, Differential
  • Female
  • Humans
  • Hyaluronan Receptors / analysis*
  • Hyaluronic Acid / analysis*
  • Male
  • Middle Aged
  • Osteoarthritis / diagnosis
  • Osteoarthritis / metabolism*
  • Sensitivity and Specificity
  • Synovial Membrane / chemistry*


  • Hyaluronan Receptors
  • Hyaluronic Acid