Extravulvar subcutaneous cellular angiofibroma

J Cutan Pathol. 1998 Jul;25(6):327-32. doi: 10.1111/j.1600-0560.1998.tb01754.x.


Cellular angiofibroma is a rare distinctive mesenchymal neoplasm of the vulva or perineal region. We report here one unique extravulvar case. A 43-year-old woman presented with an asymptomatic tumor, 7 cm in diameter, located in the subcutaneous tissue of the chest below the left submammary sulcus. Histologically, the lesion was composed of uniform spindled stroma cells, numerous thick-walled vessels, and scarce mature adipocytes. An additional feature was the presence of prominent perivascular lymphoid aggregates. The stromal cells were positive for vimentin and negative for CD34 and muscle, epithelial, myoepithelial, or neural markers. Although nasopharyngeal angiofibroma or the group of acral angiofibromas have a concurrent heading, cellular angiofibroma should not be mistaken with them. Differential diagnosis of this distinctive tumor especially includes aggressive angiomyxoma, angiomyofibroblastoma, superficial angiomyxoma, vascular myxolipoma, and other tumors with spindle cells reminiscent of those in angiofibroma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angiofibroma / chemistry
  • Angiofibroma / pathology*
  • Biomarkers, Tumor / analysis
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / pathology*


  • Biomarkers, Tumor