Improved quantification of myocardial mass by three-dimensional echocardiography using a deposit contrast agent

Ultrasound Med Biol. 1998 Jun;24(5):647-53. doi: 10.1016/s0301-5629(98)00035-0.


The aim of the study was to assess the usefulness of a novel contrast agent in combination with three-dimensional echocardiography for improved mass quantification. Three-dimensional reconstruction of left ventricular myocardium was performed from images obtained with rotational epicardial acquisition in eight open-chested pigs, before and after injection of a deposit contrast agent, Quantison Depot. Three-dimensional echocardiographic myocardial mass values were in excellent agreement with weighted mass (differences -1.6 +/- 5.0 g for end-diastolic frame, -2.8 +/- 4.5 g for end-systolic, 1.0 +/- 1.0 g for end-diastolic with contrast and 0.6 +/- 2.0 g for end-systolic with contrast, p = NS). Left ventricular mass measurements after contrast injection were more accurate and had less measurement variability. In conclusion, myocardial contrast enhancement improves left ventricular mass calculation with three-dimensional echocardiography.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Animals
  • Capsules
  • Contrast Media* / pharmacology
  • Delayed-Action Preparations
  • Echocardiography, Three-Dimensional / instrumentation
  • Echocardiography, Three-Dimensional / methods*
  • Echocardiography, Three-Dimensional / statistics & numerical data
  • Evaluation Studies as Topic
  • Heart / anatomy & histology
  • Hemodynamics / drug effects
  • Organ Size
  • Reproducibility of Results
  • Serum Albumin* / pharmacology
  • Serum Albumin, Human
  • Swine


  • Capsules
  • Contrast Media
  • Delayed-Action Preparations
  • Quantison Depot
  • Serum Albumin
  • Serum Albumin, Human