Control of cell proliferation by Myc

Trends Cell Biol. 1998 May;8(5):202-6. doi: 10.1016/s0962-8924(98)01251-3.


Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the protein Max. This review summarizes recent progress in understanding how Myc stimulates cell proliferation and how this might contribute to cellular transformation and tumorigenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / drug effects
  • Growth Substances / physiology*
  • Humans
  • Proto-Oncogene Proteins c-myc / physiology*
  • Transcription, Genetic / drug effects


  • Growth Substances
  • Proto-Oncogene Proteins c-myc