The unfolded protein response: an intracellular signalling pathway with many surprising features

Trends Cell Biol. 1998 Jun;8(6):245-9. doi: 10.1016/s0962-8924(98)01267-7.


The unfolded protein response (UPR) is an intracellular signalling pathway--originating in the endoplasmic reticulum (ER) and leading to the cell nucleus--that controls transcription of genes encoding ER-resident proteins. Recent developments in this field show that this pathway utilizes unique regulatory mechanisms, including translational attenuation and a regulated mRNA splicing step catalysed by a bifunctional transmembrane kinase/endoribonuclease and tRNA ligase. This review describes the characterization of the UPR signalling pathway, focusing on the novel regulatory mechanisms that it has revealed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Endoplasmic Reticulum / chemistry
  • Endoplasmic Reticulum / genetics*
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics*
  • Protein Folding*
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae / genetics
  • Second Messenger Systems / genetics*
  • Transcription, Genetic / physiology*


  • Nuclear Proteins