N-terminal processing: the methionine aminopeptidase and N alpha-acetyl transferase families

Trends Biochem Sci. 1998 Jul;23(7):263-7. doi: 10.1016/s0968-0004(98)01227-4.


Removal of the initiator methionine and/or acetylation of the alpha-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These events are catalyzed by methionine aminopeptidase and N alpha-acetyltransferase, respectively. Recent advances in the isolation and characterization of these enzymes indicate that they exist as isoforms that vary in cellular location, function, and evolutionary origins.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetyltransferases / chemistry
  • Acetyltransferases / genetics
  • Acetyltransferases / metabolism*
  • Aminopeptidases / chemistry
  • Aminopeptidases / genetics
  • Aminopeptidases / metabolism*
  • Animals
  • Evolution, Molecular
  • Humans
  • Methionyl Aminopeptidases
  • Models, Molecular
  • Protein Conformation
  • Protein Processing, Post-Translational


  • Acetyltransferases
  • Aminopeptidases
  • Methionyl Aminopeptidases