Gene clusters and polycistronic transcription in eukaryotes

Bioessays. 1998 Jun;20(6):480-7. doi: 10.1002/(SICI)1521-1878(199806)20:6<480::AID-BIES6>3.0.CO;2-Q.


Sometimes genes are arranged nonrandomly on the chromosomes of eukaryotes. This review considers instances of gene clusters in which two genes or more are expressed from a single promoter. This includes cases in which a polycistronic pre-mRNA is processed to make monocistronic mRNAs in nematodes, as well as isolated examples of polycistronic mRNAs found in mammals, flies, and perhaps plants.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Base Sequence
  • Caenorhabditis elegans / genetics
  • Drosophila / genetics
  • Eukaryotic Cells
  • Evolution, Molecular
  • Genes*
  • Multigene Family*
  • Operon
  • Plants / genetics
  • RNA, Messenger / genetics
  • Transcription, Genetic
  • Trypanosoma / genetics


  • RNA, Messenger