In-vitro activity of voriconazole against Aspergillus spp. and comparison with itraconazole and amphotericin B

J Antimicrob Chemother. 1998 Jul;42(1):91-4. doi: 10.1093/jac/42.1.91.


The in-vitro activity of the triazole antifungal agent voriconazole was compared with itraconazole and amphotericin B against 60 aspergillus isolates. Susceptibility tests were performed using two methods: a macrodilution and a microdulution method. For macrodilution methodology, geometric mean (GM) MIC values and ranges were 0.4 and 0.125-4 mg/L for voriconazole, 0.24 and 0.06-->16 mg/L for itraconazole, and 1.04 and 0.5-4 mg/L for amphotericin B. For the microdilution method, GM MICs and ranges were 0.66 and 0.125-2 mg/L for voriconazole, 0.27 and 0.06-->16 mg/L for itraconazole, and 1.62 and 0.25-32 mg/L for amphotericin B. In conclusion, voriconazole is active against Aspergillus spp. in vitro, and at similar concentrations to itraconazole.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology*
  • Aspergillus / drug effects*
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests
  • Pyrimidines / pharmacology*
  • Triazoles / pharmacology*
  • Voriconazole


  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • Amphotericin B
  • Voriconazole