Epilepsy in patients with multiple sclerosis: radiological-clinical correlations

Epilepsia. 1998 Aug;39(8):893-6. doi: 10.1111/j.1528-1157.1998.tb01187.x.


Purpose: To determine potential mechanisms of epilepsy in patients with multiple sclerosis (MS).

Methods: Among 402 patients with clinically and radiologically defined MS, including de novo cases, presenting to the Neurology Service, University Hospital of Dijon, we identified 17 with epileptic seizures (4.25%). Among them, the percentage with partial seizures (50%) was greater than that in the reference population.

Results: In most of the patients with MS, plaques were localized in the frontal region, associated with frontal and callosal atrophy, a frontal syndrome, and severe disability status (as assessed by a standard scale). Magnetic resonance imaging (MRI) showed numerous subcortical plaques. Seizures generally were well controlled with antiepileptic drugs (AEDs).

Conclusions: Our data suggest that the subcortical plaques of MS underlie seizure activity in patients with MS and epilepsy.

MeSH terms

  • Adult
  • Age of Onset
  • Atrophy
  • Brain / pathology
  • Cerebral Cortex / pathology
  • Cerebral Ventricles / pathology
  • Comorbidity
  • Corpus Callosum / pathology
  • Disability Evaluation
  • Electroencephalography
  • Epilepsies, Partial / diagnosis
  • Epilepsies, Partial / epidemiology
  • Epilepsies, Partial / pathology
  • Epilepsy / diagnosis
  • Epilepsy / epidemiology*
  • Epilepsy / pathology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / pathology
  • Prevalence