We have suggested from previous studies that increases in early neonatal epidermal growth factor (EGF) concentrations were dependent on adequate glucocorticoid hormone concentrations. In order to examine this relationship, matched values for cortisol and EGF in 193 preterm infants on days 2 and 6 were compared. Gestational age had a significant positive effect on EGF concentrations for those infants receiving oral nutrition and there was also a positive relationship between nutrition and cortisol concentration. Cortisol was then used as an independent factor and was significantly (p = 0. 01) related to EGF values such that as cortisol concentrations increased, EGF values also increased. In summary, we suggest that these results are consistent with a role for cortisol in the control of the EGF pattern in the newborn period.