Abstract
Some N-benzenesulphonyl-2(2- or 3-pyridylethyl)-benzimidazoles were synthesized and tested in vitro for antiproliferative and antiviral activity. Only one compound displayed a degree of antiproliferative activity against chronic myeloid leukaemia cells. However, a number of them exerted an antiviral effect at micromolar concentrations. The antiproliferative activity and the maximum potency of antiviral activity correlate with the presence of both the 2-pyridyl moiety bound at the ethylenic bridge in C-2 of benzimidazole and the nitro group in the benzene ring.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Benzenesulfonates / chemical synthesis*
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Benzenesulfonates / pharmacology
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology
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Cell Division / drug effects
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Chlorocebus aethiops
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Chromatography, Thin Layer
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
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Magnetic Resonance Spectroscopy
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Pyridines / chemical synthesis*
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Pyridines / pharmacology
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Tumor Cells, Cultured
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Vero Cells
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Viral Plaque Assay
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Viruses / drug effects
Substances
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Antiviral Agents
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Benzenesulfonates
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Benzimidazoles
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Pyridines