Resistance training improves insulin sensitivity in NIDDM subjects without altering maximal oxygen uptake

Diabetes Care. 1998 Aug;21(8):1353-5. doi: 10.2337/diacare.21.8.1353.


Objective: To examine the effect of resistance training on insulin sensitivity in nonobese NIDDM patients.

Research design and methods: Previously sedentary nonobese NIDDM patients were enrolled in a resistance training group (RT; n = 9) or used as sedentary control subjects (SED; n = 8). SED subjects did not perform exercise training because of orthopedic disorders. The training program consisted of two sets of nine exercises with 10-20 repetitions. Subjects trained five times a week for 4-6 weeks. Insulin sensitivity, as assessed by the hyper-insulinemic-euglycemic clamp technique, HbAJc, and body composition, was measured before and after the training period. Maximal oxygen uptake (VO2max) and quadriceps strength were measured in the RT group.

Results: The two groups did not differ significantly on any variables before participation in the program. The glucose disposal rate during the hyperinsulinemic-euglycemic clamp increased 48% in the RT group (6.85 +/- 1.86 to 10.12 +/- 3.15 lean body mass.min-1; P < 0.05), but remained unchanged in the SED group (5.95 +/- 1.63 to 6.36 +/- 1.61 lean body mass.min-1). There was no significant change in body composition in either group. In the RT group, a 16% increase in quadriceps strength (191.1 +/- 45.8 to 216.9 +/- 42.8 Nm; P < 0.05) but no significant change (27.6 +/- 5.0 to 28.6 +/- 6.5 in VO2max was observed.

Conclusions: Moderate-intensity, high-volume resistance training improves insulin sensitivity in nonobese NIDDM without altering VO2max.

Publication types

  • Comparative Study

MeSH terms

  • Body Composition
  • Body Weight
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Exercise / physiology*
  • Exercise Test
  • Glucose Clamp Technique
  • Glycated Hemoglobin / analysis
  • Humans
  • Infusions, Intravenous
  • Insulin / administration & dosage
  • Insulin / blood
  • Insulin / pharmacology*
  • Middle Aged
  • Oxygen Consumption*
  • Physical Fitness


  • Glycated Hemoglobin A
  • Insulin