Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review

Pathol Int. 1998 Jun;48(6):471-4. doi: 10.1111/j.1440-1827.1998.tb03935.x.


A case of ovarian mixed germ cell tumor in a 44-year-old woman was examined. The tumor was well circumscribed, measured 15 x 11 x 10 cm and appeared solid and partly cystic on the cut surface. Light microscopic examinations revealed that the tumor was composed of four different neoplastic germ cell elements, intermingled with each other. They are: (i) choriocarcinoma, immunohistochemically positive for human placental lactogen (hPL) and human chorionic gonadotropin (hCG); (ii) dysgerminoma, positive for placental alkaline phosphatase; (iii) endodermal sinus tumor positive for alpha-fetoprotein (AFP); and (iv) mature teratoma. Among these histological types, dysgerminoma occupied more than 50% of the neoplasm. The patient was diagnosed as a stage la ovarian mixed germ cell tumor and was subsequently treated with chemotherapy. A second-look laparotomy after completion of chemotherapy revealed no residual tumors in the abdomen and the patient is alive and well 15 months after operation. This is the fourth reported case of ovarian mixed germ cell tumor arising in patients over 40 years old.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Alkaline Phosphatase / metabolism
  • Choriocarcinoma / metabolism
  • Choriocarcinoma / pathology*
  • Chorionic Gonadotropin / metabolism
  • Dysgerminoma / enzymology
  • Dysgerminoma / pathology*
  • Endodermal Sinus Tumor / metabolism
  • Endodermal Sinus Tumor / pathology*
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology*
  • Placental Lactogen / metabolism
  • Teratoma / metabolism
  • Teratoma / pathology*
  • alpha-Fetoproteins / metabolism


  • Chorionic Gonadotropin
  • alpha-Fetoproteins
  • Placental Lactogen
  • Alkaline Phosphatase