Second primary tumours in more than 2-year disease-free survivors of small-cell lung cancer in Japan: the role of smoking cessation

Br J Cancer. 1998 Aug;78(3):409-12. doi: 10.1038/bjc.1998.507.


Patients with small-cell lung cancer who survive more than 2 years have a significantly increased risk (relative risk of 3.6) of developing a second primary tumour. The cessation of cigarette smoking after successful therapy is associated with a significantly decreased risk of a second primary tumour.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carcinoma, Small Cell / epidemiology*
  • Disease-Free Survival
  • Female
  • Humans
  • Lung Neoplasms / epidemiology*
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / epidemiology*
  • Risk
  • Smoking Cessation