Analysis of organic acids, amino acids, and carnitine in dogs with lipid storage myopathy

Muscle Nerve. 1998 Sep;21(9):1202-5. doi: 10.1002/(sici)1097-4598(199809)21:9<1202::aid-mus13>;2-t.


Abnormal accumulations of lipid droplets, localized predominantly in histochemical type 1 fibers, were observed in fresh frozen sections of muscle biopsies from 25 dogs with myalgia, weakness, and muscle atrophy. Compared to controls, lactic acidemia, hyperalaninemia, lactic and pyruvic aciduria, variably increased urinary excretion of carnitine esters, and muscle carnitine deficiency were present. These findings support a metabolic block in oxidative metabolism resulting in lactic acidemia in dogs with lipid storage myopathy.

MeSH terms

  • Acids / urine*
  • Amino Acids / blood*
  • Animals
  • Carnitine / metabolism*
  • Dog Diseases / metabolism*
  • Dog Diseases / pathology
  • Dogs
  • Female
  • Lipid Metabolism*
  • Male
  • Muscles / metabolism
  • Muscles / pathology
  • Muscular Diseases / veterinary*


  • Acids
  • Amino Acids
  • Carnitine